Protein-coding gene in the species Homo sapiens
PTPRA Identifiers Aliases PTPRA External IDs OMIM : 176884 ; MGI : 97808 ; HomoloGene : 20621 ; GeneCards : PTPRA ; OMA :PTPRA - orthologs Wikidata
Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene .[ 5] [ 6] [ 7]
Function The protein encoded by this gene is a member of the receptor tyrosine phosphatases (RTP), a family of protein tyrosine phosphatases . RTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This RTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type RTP. This RTP has been shown to dephosphorylate and activate Src family tyrosine kinases,[ 8] [ 7]
Interactions PTPRA has been shown to interact with Grb2 [ 9] [ 10] [ 11] KCNA2 .[ 12]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000132670 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027303 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Jirik FR, Janzen NM, Melhado IG, Harder KW (December 1990). "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase" . FEBS Lett . 273 (1–2): 239–42. Bibcode :1990FEBSL.273..239J . doi :10.1016/0014-5793(90)81094-5 PMID 2172030 . S2CID 31501542 . ^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J (October 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain" . Proc Natl Acad Sci U S A . 87 (18): 7000–4. Bibcode :1990PNAS...87.7000K . doi :10.1073/pnas.87.18.7000 PMC 54670 PMID 2169617 . ^ a b "Entrez Gene: PTPRA protein tyrosine phosphatase, receptor type, A" .^ den Hertog J, Pals CE, Peppelenbosch MP, Tertoolen LG, de Laat SW, Kruijer W (1993). "Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation" . EMBO Journal . 12 (10): 3789–98. doi :10.1002/j.1460-2075.1993.tb06057.x PMC 413662 PMID 7691597 . ^ den Hertog J, Hunter T (June 1996). "Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains" . EMBO J . 15 (12): 3016–27. doi :10.1002/j.1460-2075.1996.tb00665.x . PMC 450243 PMID 8670803 . ^ den Hertog J, Tracy S, Hunter T (July 1994). "Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo" . EMBO J . 13 (13): 3020–32. doi :10.1002/j.1460-2075.1994.tb06601.x . PMC 395191 PMID 7518772 . ^ Zheng XM, Resnick RJ, Shalloway D (June 2002). "Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation" . J. Biol. Chem . 277 (24): 21922–9. doi :10.1074/jbc.M201394200 PMC 5641391 PMID 11923305 . ^ Tsai W, Morielli AD, Cachero TG, Peralta EG (January 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity" . EMBO J . 18 (1): 109–18. doi :10.1093/emboj/18.1.109 . PMC 1171107 PMID 9878055 .
Further reading
Mustelin T, Hunter T (2002). "Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha". Sci. STKE . 2002 (115): PE3. doi :10.1126/stke.2002.115.pe3 . PMID 11796915 . S2CID 1111167 . Zheng XM, Wang Y, Pallen CJ (1992). "Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase". Nature . 359 (6393): 336–9. Bibcode :1992Natur.359..336Z . doi :10.1038/359336a0 . PMID 1383828 . S2CID 1283722 . Jirik FR, Anderson LL, Duncan AM (1992). "The human protein-tyrosine phosphatase PTP alpha/LRP gene (PTPA) is assigned to chromosome 20p13". Cytogenet. Cell Genet . 60 (2): 117–8. doi :10.1159/000133317 . PMID 1611910 . Rao VV, Löffler C, Sap J, Schlessinger J, Hansmann I (1992). "The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is assigned to human chromosome 20p12-pter by in situ hybridization (ISH and FISH)". Genomics . 13 (3): 906–7. doi :10.1016/0888-7543(92)90186-V . PMID 1639427 . Sap J, D'Eustachio P, Givol D, Schlessinger J (1990). "Cloning and expression of a widely expressed receptor tyrosine phosphatase" . Proc. Natl. Acad. Sci. U.S.A . 87 (16): 6112–6. Bibcode :1990PNAS...87.6112S . doi :10.1073/pnas.87.16.6112 PMC 54482 PMID 2166945 . Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases" . EMBO J . 9 (10): 3241–52. doi :10.1002/j.1460-2075.1990.tb07523.x . PMC 552056 PMID 2170109 . Ohagi S, Nishi M, Steiner DF (1991). "Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide)" . Nucleic Acids Res . 18 (23): 7159. doi :10.1093/nar/18.23.7159 . PMC 332805 PMID 2175890 . den Hertog J, Tracy S, Hunter T (1994). "Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo" . EMBO J . 13 (13): 3020–32. doi :10.1002/j.1460-2075.1994.tb06601.x . PMC 395191 PMID 7518772 . den Hertog J, Pals CE, Peppelenbosch MP, Tertoolen LG, de Laat SW, Kruijer W (1993). "Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation" . EMBO J . 12 (10): 3789–98. doi :10.1002/j.1460-2075.1993.tb06057.x . PMC 413662 PMID 7691597 . Stover DR, Furet P, Lydon NB (1996). "Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain" . J. Biol. Chem . 271 (21): 12481–7. doi :10.1074/jbc.271.21.12481 PMID 8647855 . den Hertog J, Hunter T (1996). "Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains" . EMBO J . 15 (12): 3016–27. doi :10.1002/j.1460-2075.1996.tb00665.x . PMC 450243 PMID 8670803 . Shimizu Y, Sugiyama H, Fujii Y, Sasaki K, Inoue K, Ogawa H, Tamaki H, Miyake S, Oji Y, Soma T, Yamagami T, Hirata M, Ikeda K, Monden T, Kishimoto T (1997). "Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells". Am. J. Hematol . 54 (1): 1–11. doi :10.1002/(SICI)1096-8652(199701)54:1<1::AID-AJH1>3.0.CO;2-1 . PMID 8980254 . S2CID 36581335 . Lim KL, Lai DS, Kalousek MB, Wang Y, Pallen CJ (1997). "Kinetic analysis of two closely related receptor-like protein-tyrosine-phosphatases, PTP alpha and PTP epsilon" . Eur. J. Biochem . 245 (3): 693–700. doi :10.1111/j.1432-1033.1997.00693.x PMID 9183007 . Somani AK, Bignon JS, Mills GB, Siminovitch KA, Branch DR (1997). "Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase" . J. Biol. Chem . 272 (34): 21113–9. doi :10.1074/jbc.272.34.21113 PMID 9261115 . Feito MJ, Bragardo M, Buonfiglio D, Bonissoni S, Bottarel F, Malavasi F, Dianzani U (1997). "gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules" . Int. Immunol . 9 (8): 1141–7. doi :10.1093/intimm/9.8.1141 PMID 9263011 . Norris K, Norris F, Kono DH, Vestergaard H, Pedersen O, Theofilopoulos AN, Møller NP (1997). "Expression of protein-tyrosine phosphatases in the major insulin target tissues". FEBS Lett . 415 (3): 243–8. Bibcode :1997FEBSL.415..243N . doi :10.1016/S0014-5793(97)01133-2 . PMID 9357975 . S2CID 9414519 . Bhandari V, Lim KL, Pallen CJ (1998). "Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn" . J. Biol. Chem . 273 (15): 8691–8. doi :10.1074/jbc.273.15.8691 PMID 9535845 . Harder KW, Moller NP, Peacock JW, Jirik FR (1998). "Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion" . J. Biol. Chem . 273 (48): 31890–900. doi :10.1074/jbc.273.48.31890 PMID 9822658 .
PDB gallery
1p15 : Crystal structure of the D2 domain of RPTPa
1yfo : RECEPTOR PROTEIN TYROSINE PHOSPHATASE ALPHA, DOMAIN 1 FROM MOUSE
