Protein-coding gene in the species Homo sapiens
Polo-like kinase 3 (Drosophila) , also known as PLK3 , is an enzyme which in humans is encoded by the PLK3 gene .[ 5] [ 6]
Function Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis .[ 5]
Interactions PLK3 has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000173846 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028680 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)" .^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas" . J. Biol. Chem . 271 (32): 19402– 8. doi :10.1074/jbc.271.32.19402 PMID 8702627 . ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk" . Oncogene . 18 (44): 6029– 36. doi :10.1038/sj.onc.1202983 PMID 10557092 . ^ a b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene . 21 (43): 6633– 40. doi :10.1038/sj.onc.1205850 . PMID 12242661 . S2CID 24106070 . ^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway" . J. Biol. Chem . 276 (46): 43305– 12. doi :10.1074/jbc.M106050200 PMID 11551930 .
Further reading
Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas" . J. Biol. Chem . 271 (32): 19402– 8. doi :10.1074/jbc.271.32.19402 PMID 8702627 . Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997). "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216". Science . 277 (5331): 1501– 5. doi :10.1126/science.277.5331.1501 . PMID 9278512 . Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W (1997). "Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions" . J. Biol. Chem . 272 (45): 28646– 51. doi :10.1074/jbc.272.45.28646 PMID 9353331 . Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity" . EMBO J . 18 (20): 5528– 39. doi :10.1093/emboj/18.20.5528 . PMC 1171621 PMID 10523297 . Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk" . Oncogene . 18 (44): 6029– 36. doi :10.1038/sj.onc.1202983 PMID 10557092 . Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). "The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites" . Genes Dev . 14 (3): 289– 300. doi :10.1101/gad.14.3.289 . PMC 316358 PMID 10673501 . Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P (2000). "PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer". Genes Chromosomes Cancer . 27 (3): 332– 6. doi :10.1002/(SICI)1098-2264(200003)27:3<332::AID-GCC15>3.0.CO;2-K . PMID 10679924 . S2CID 20642025 . Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000). "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro" . Proc. Natl. Acad. Sci. U.S.A . 97 (19): 10389– 94. Bibcode :2000PNAS...9710389M . doi :10.1073/pnas.190030497 PMC 27034 PMID 10973490 . Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene . 19 (42): 4832– 9. doi :10.1038/sj.onc.1203845 . PMID 11039900 . S2CID 25807289 . Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ (2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature . 411 (6833): 102– 7. Bibcode :2001Natur.411..102B . doi :10.1038/35075107 . PMID 11333986 . S2CID 4410763 . Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway" . J. Biol. Chem . 276 (46): 43305– 12. doi :10.1074/jbc.M106050200 PMID 11551930 . Latonen L, Taya Y, Laiho M (2001). "UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts" . Oncogene . 20 (46): 6784– 93. doi :10.1038/sj.onc.1204883 PMID 11709713 . Ahn JY, Li X, Davis HL, Canman CE (2002). "Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain" . J. Biol. Chem . 277 (22): 19389– 95. doi :10.1074/jbc.M200822200 PMID 11901158 . Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM (2002). "The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase" . Mol. Cell . 9 (3): 515– 25. doi :10.1016/S1097-2765(02)00473-2 PMID 11931760 . Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W (2002). "Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity" . Mol. Cell. Biol . 22 (10): 3450– 9. doi :10.1128/MCB.22.10.3450-3459.2002 . PMC 133784 PMID 11971976 . Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene . 21 (43): 6633– 40. doi :10.1038/sj.onc.1205850 . PMID 12242661 . S2CID 24106070 . Tsvetkov L, Xu X, Li J, Stern DF (2003). "Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody" . J. Biol. Chem . 278 (10): 8468– 75. doi :10.1074/jbc.M211202200 PMID 12493754 . Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W (2003). "Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2" . Cell Cycle . 1 (6): 424– 9. doi :10.4161/cc.1.6.271 PMID 12548019 . Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004). "Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation" . Oncogene . 23 (15): 2658– 63. doi :10.1038/sj.onc.1207425 PMID 14968113 .
Activity Regulation Classification Kinetics Types
