Protein-coding gene in the species Homo sapiens
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene .[ 4] [ 5]
A recent study on gene expression indicated that the PIK3R2 gene might have a key role in pan-cancer prognosis.[ 6]
Interactions PIK3R2 has been shown to interact with:
Clinical relevance PIK3R2 mutations were recently shown to be associated with polymicrogyria .[ 12]
References
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031834 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Volinia S, Patracchini P, Otsu M, Hiles I, Gout I, Calzolari E, et al. (April 1992). "Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta". Oncogene . 7 (4): 789– 793. PMID 1314371 . ^ "Entrez Gene: PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)" .^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning" . BioData Mining . 15 (1): 28. doi :10.1186/s13040-022-00312-y eISSN 1756-0381 . PMC 9632055 PMID 36329531 . ^ Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)" . The Journal of Biological Chemistry . 272 (15): 10248– 10253. doi :10.1074/jbc.272.15.10248 PMID 9092574 . ^ Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation" . International Immunology . 13 (1): 13– 22. doi :10.1093/intimm/13.1.13 PMID 11133830 . ^ Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl" . The Journal of Biological Chemistry . 270 (31): 18260– 18263. doi :10.1074/jbc.270.31.18260 PMID 7629144 . ^ a b c d Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system" . The Biochemical Journal . 288 ( Pt 2) (2): 395– 405. doi :10.1042/bj2880395 . PMC 1132024 PMID 1334406 . ^ Vanhaesebroeck B, Welham MJ , Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes" . Proceedings of the National Academy of Sciences of the United States of America . 94 (9): 4330– 4335. Bibcode :1997PNAS...94.4330V . doi :10.1073/pnas.94.9.4330 PMC 20722 PMID 9113989 . ^ Mirzaa GM, Conti V, Timms AE, Smyser CD, Ahmed S, Carter M, et al. (December 2015). "Characterisation of mutations of the phosphoinositide-3-kinase regulatory subunit, PIK3R2, in perisylvian polymicrogyria: a next-generation sequencing study" . The Lancet. Neurology . 14 (12): 1182– 1195. doi :10.1016/S1474-4422(15)00278-1 . PMC 4672724 PMID 26520804 .
Further reading
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG (November 2003). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways" . Journal of Leukocyte Biology . 74 (5): 676– 682. doi :10.1189/jlb.0503206 PMID 12960231 . S2CID 11362623 . Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD (December 1992). "Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system" . The Biochemical Journal . 288 ( Pt 2) (2): 395– 405. doi :10.1042/bj2880395 . PMC 1132024 PMID 1334406 . Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (November 1990). "Purification and characterization of phosphoinositide 3-kinase from rat liver" . The Journal of Biological Chemistry . 265 (32): 19704– 19711. doi :10.1016/S0021-9258(17)45429-9 PMID 2174051 . Truitt KE, Hicks CM, Imboden JB (March 1994). "Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells" . The Journal of Experimental Medicine . 179 (3): 1071– 1076. doi :10.1084/jem.179.3.1071 . PMC 2191424 PMID 7509360 . Herbst R, Shearman MS, Jallal B, Schlessinger J, Ullrich A (May 1995). "Formation of signal transfer complexes between stem cell and platelet-derived growth factor receptors and SH2 domain proteins in vitro". Biochemistry . 34 (17): 5971– 5979. doi :10.1021/bi00017a026 . PMID 7537096 . Craparo A, O'Neill TJ, Gustafson TA (June 1995). "Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor" . The Journal of Biological Chemistry . 270 (26): 15639– 15643. doi :10.1074/jbc.270.26.15639 PMID 7541045 . He W, O'Neill TJ, Gustafson TA (October 1995). "Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains" . The Journal of Biological Chemistry . 270 (40): 23258– 23262. doi :10.1074/jbc.270.40.23258 PMID 7559478 . Kapeller R, Toker A, Cantley LC, Carpenter CL (October 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin" . The Journal of Biological Chemistry . 270 (43): 25985– 25991. doi :10.1074/jbc.270.43.25985 PMID 7592789 . Hartley D, Meisner H, Corvera S (August 1995). "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl" . The Journal of Biological Chemistry . 270 (31): 18260– 18263. doi :10.1074/jbc.270.31.18260 PMID 7629144 . Pandey A, Lazar DF, Saltiel AR, Dixit VM (December 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity" . The Journal of Biological Chemistry . 269 (48): 30154– 30157. doi :10.1016/S0021-9258(18)43790-8 PMID 7982920 . August A, Dupont B (May 1994). "CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase". International Immunology . 6 (5): 769– 774. doi :10.1093/intimm/6.5.769 . PMID 8080844 . Fukazawa T, Miyake S, Band V, Band H (June 1996). "Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins" . The Journal of Biological Chemistry . 271 (24): 14554– 14559. doi :10.1074/jbc.271.24.14554 PMID 8662998 . Milani D, Mazzoni M, Borgatti P, Zauli G, Cantley L, Capitani S (September 1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells" . The Journal of Biological Chemistry . 271 (38): 22961– 22964. doi :10.1074/jbc.271.38.22961 PMID 8798481 . Sattler M, Salgia R, Shrikhande G, Verma S, Pisick E, Prasad KV, Griffin JD (April 1997). "Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)" . The Journal of Biological Chemistry . 272 (15): 10248– 10253. doi :10.1074/jbc.272.15.10248 PMID 9092574 . Vanhaesebroeck B, Welham MJ , Kotani K, Stein R, Warne PH, Zvelebil MJ, et al. (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes" . Proceedings of the National Academy of Sciences of the United States of America . 94 (9): 4330– 4335. Bibcode :1997PNAS...94.4330V . doi :10.1073/pnas.94.9.4330 PMC 20722 PMID 9113989 . Briand G, Barbeau B, Tremblay M (February 1997). "Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase" . Virology . 228 (2): 171– 179. doi :10.1006/viro.1996.8399 PMID 9123823 . Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, et al. (June 1997). "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site" . Oncogene . 14 (22): 2619– 2631. doi :10.1038/sj.onc.1201123 PMID 9178760 . Shepherd PR, Navé BT, Rincon J, Nolte LA, Bevan AP, Siddle K, et al. (July 1997). "Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle" . The Journal of Biological Chemistry . 272 (30): 19000– 19007. doi :10.1074/jbc.272.30.19000 PMID 9228082 . Mazerolles F, Barbat C, Fischer A (September 1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity". European Journal of Immunology . 27 (9): 2457– 2465. doi :10.1002/eji.1830270946 . PMID 9341793 . S2CID 33397908 .
