Owl Creek may refer to:

• Owl Creek (Colorado)
• Owl Creek (North Fork Charrette Creek), a stream in Missouri
• Owl Creek (North River), a stream in Missouri
• Owl Creek (Sni-A-Bar Creek), a stream in Missouri
• Owl Creek (Sugar Creek), a stream in Missouri
• Owl Creek, North Carolina, an unincorporated community
• Owl Creek (Wisconsin), a stream in Wisconsin
• Owl Creek Mountains, Wyoming
• Owl Creek, Wyoming, a census-designated place
• Owl Creek, a firing range at Fort Cavazos, Texas

• "An Occurrence at Owl Creek Bridge", a short story by Ambrose Bierce (also adapted into a film of the same name)