Otis may refer to:

• Otis (film), a direct-to-DVD 2008 American comedy horror film
• "Otis" (The Jeffersons), a television episode
• "Otis" (Prison Break), a television episode

• Otis (Brian McFadden album), 2019
• Otis (Mojo Nixon album), 1990
• "Otis" (song), by Jay-Z and Kanye West, 2011
• "Otis", a song by Magma from Merci, 1985
• "Otis", a song by Medeski Martin & Wood from Notes from the Underground, 1992
• "Otis", a song by The Durutti Column from 24 Hour Party People (soundtrack), 2002
• "Otis", a song by John Medeski from A Different Time, 2013

• Otis (given name), a list of people and fictional characters
• Otis (surname), a list of people
• Otis (wrestler), a ring name of American professional wrestler Nikola Bogojević (born 1991)
• Otis family, an American political family
• Otis, American rapper in the duo Axe Murder Boyz

• Otis, Colorado, a Statutory Town
• Otis, Indiana, an unincorporated community
• Otis, Iowa, a neighborhood of Cedar Rapids
• Otis, Kansas, a city
• Otis, Louisiana, an unincorporated community
• Otis, Maine, a town
• Otis, Massachusetts, a town
• Otis, Oregon, an unincorporated community
• Otis, Wisconsin, an unincorporated community
• Otis Peak, a mountain in Colorado
• Otis Air National Guard Base, Cape Cod, Massachusetts

• Mount Otis, Marie Byrd Land

• Otis Worldwide, American manufacturer of elevators, escalators, and related systems
• Otis College of Art and Design, in Los Angeles, California, US
• Otis Hotel, a historic building in Spokane, Washington, US
• Otis (bird), a genus of bustard
• List of storms named Otis, various tropical cyclones baring the name

• All pages with titles beginning with Otis
• All pages with titles containing Otis
• Otis tarda, or great bustard, a bird
• Ohtis, an American country rock band