Odyssey II, Odyssey 2, Odyssey Two, may refer to:

• Odyssey 2 (game console), a videogame console from Magnavox and Philips
• 2010: Odyssey Two (novel), a 1982 science fiction novel by Arthur C. Clarke
• Odyssey II (fictional TV spacecraft), a fictional spaceship from the 2020 U.S. TV show The Astronauts (TV series)
• Odyssey II (TV channel), former name of MEGA Cosmos (Canada)
• "The Odyssey II" (TV episode), a 1962 season 8 episode of Lassie; see List of Lassie (1954 TV series) episodes
• Odyssey II: The Return of Odysseus (film), a 1965 film from Encyclopædia Britannica Films; see List of Encyclopædia Britannica Films titles

• The second epic poem of the Epic Cycle/Trojan Cycle of the Illiad and the Odyssey of Ancient Greece
• 2010: The Year We Make Contact (film), a 1984 film based on the 1982 novel 2010: Odyssey Two
• A Second Odyssey (poem), an 1894 poem by Constantine P. Cavafy; a prior version of Ithaca (poem)
• All pages with titles containing odyssey two
• All pages with titles containing odyssey ii
• All pages with titles containing odyssey 2
• Odyssey (disambiguation)
• Odyssey I (disambiguation)
• Odyssey II (disambiguation)
• Odyssey III (disambiguation)