Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1gene.[5]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors arising from single coding-exon genes. Olfactory receptors share a 7-transmembranedomain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
The receptor is associated with some compounds with a "cheese" or "sour" scent note.
Examples of compounds that activate OR51E1 include:
^ abFujita Y, Takahashi T, Suzuki A, Kawashima K, Nara F, Koishi R (2007). "Deorphanization of Dresden G protein-coupled receptor for an odorant receptor". Journal of Receptor and Signal Transduction Research. 27 (4): 323–34. doi:10.1080/10799890701534180. PMID17885925. S2CID42999502.
Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M (June 2006). "The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase". The Prostate. 66 (8): 847–57. doi:10.1002/pros.20389. PMID16491480. S2CID25548828.
Weng J, Wang J, Hu X, Wang F, Ittmann M, Liu M (March 2006). "PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer". International Journal of Cancer. 118 (6): 1471–80. doi:10.1002/ijc.21527. PMID16206286. S2CID23711956.
Weigle B, Fuessel S, Ebner R, Temme A, Schmitz M, Schwind S, et al. (September 2004). "D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate". Biochemical and Biophysical Research Communications. 322 (1): 239–49. doi:10.1016/j.bbrc.2004.07.106. PMID15313197.
