Coyne is a surname of Irish origin anglicised from the Gaelic Ó Cadhain meaning "descendant of Cadhan".

Notable people with the surname include:

• Andre Coyne, dam engineer
• Andrew Coyne, journalist
• Bernard Coyne (bishop), Bishop of Elphin from 1913 to 1926
• Bernard Coyne (giant) (1897–1921), American who is one of only 20 individuals in medical history to have stood 240 cm (8 feet) or more
• Brian Coyne (born 1959), Scottish (soccer) football player and manager
• Christopher Coyne (disambiguation), multiple people

• Christopher J. Coyne (born 1958), bishop of the Roman Catholic Diocese of Burlington, Vermont
• Christopher Coyne (professor) (born 1977), professor of economics
• Chris Coyne (born 1978), Australian (soccer) footballer
• Chris Coyne, co-founded the websites OkCupid, keybase and SparkNotes

• Dale Coyne, auto racer
• Danny Coyne, footballer
• Deborah Coyne, lawyer, professor and author
• Frank J. Coyne, CEO of Insurance Services Office, Inc.
• Gary Coyne (born 1961), Australian rugby league footballer
• George Coyne, priest and astronomer
• James Coyne (disambiguation), several people

• James C. Coyne (born 1947), American psychologist
• James Elliott Coyne (1910–2012), governor of the Bank of Canada, son of J. Bowes
• James Henry Coyne (1849–1942), Canadian lawyer and historian
• James K. Coyne III (born 1946), U.S. Representative from Pennsylvania

• Jamie Coyne (born 1982), Australian (soccer) footballer, brother of Chris Coyne
• Jeanne Coyne, Broadway dancer and choreographer
• Jerry Coyne, American professor of biology
• John Coyne (disambiguation), several people

• John Coyne (politician) (1836–1873), Canadian barrister and politician
• John Coyne (writer) (born 1937), American writer of horror novels
• John Henry Coyne aka Harry Coyne (1865–1926), Queensland politician
• John M. Coyne (1916–2014), former mayor of Brooklyn, Ohio
• John Coyne (footballer) (born 1951), English-born football (soccer) player who played for Australia
• John N. Coyne (1839–1907), American Civil War soldier

• Joseph Coyne, American stage actor who achieved fame in musical comedy
• Joseph Stirling Coyne, Prolific British playwright from the mid-nineteenth century
• Joshua Coyne, American classical musician
• Kevin Coyne, composer, writer and painter
• Mark Coyne (musician), American musician
• Mark Coyne (rugby league), Australian rugby league footballer
• Máirtín Ó Cadhain, Irish-language modernist writer
• Michael L. Coyne, Associate Dean and Law Professor at the Massachusetts School of Law
• Paul Coyne, TV & film producer
• Peter Coyne (disambiguation), several people with that name

• Peter Coyne (footballer) (born 1958), English footballer
• Peter Coyne (politician) (1917–2001), Australian politician
• Peter Coyne (rugby league) (born 1964), Australian rugby league player

• Richard Coyne, Professor of Architectural Computing
• Thelma Coyne, tennis player
• Wayne Coyne, musician
• William J. Coyne, American politician
• Evan Coyne Maloney, documentary filmmaker and video blogger
• Lydia Coyne Fletcher (1853–1904), Irish-American playwright, novelist

Fictional characters

• Declan Coyne, in Degrassi: The Next Generation
• Fiona Coyne, in Degrassi: The Next Generation
• Joe Coyne, aka "Penny Plunderer", a villain appearing in Batman comics