Nicolini may refer to:

• 15386 Nicolini, main-belt asteroid named after the astronomer Martino Nicolini

• Stage name of Nicolo Grimaldi (1673–1732), Italian mezzo-soprano castrato
• Angelo Nicolini (1505–1567), Italian cardinal
• Bruno Nicolini (born 1969), civil name of the French singer Bénabar
• Emanuele Nicolini (1984), Sammarinese swimmer
• Enrico Nicolini (born 1955), Italian former professional footballer and manager
• Ernesto Nicolini (1834–1898), French operatic tenor
• Giuseppe Nicolini (composer) (1762–1842), Italian composer
• Giuseppe Nicolini (sculptor) (1855–?), Italian sculptor
• Giuseppe Nicolini (writer) (1788–1855), Italian writer
• Giuseppe Placido Nicolini O.S.B. (1877–1973), Roman Catholic Bishop of Assisi
• Gregorio González Nicolini (born 1974), Chilean film producer and financial engineer
• Ignacio Nicolini (born 1988), Uruguayan footballer
• Jill Nicolini (born 1978), American model, actress and reality TV show participant
• Michelle Nicolini (born 1982), Brazilian Jiu-Jitsu practitioner and mixed martial artist

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