Nicholas Lambrinides (1879–1962) was a Greek-American entrepreneur who built the Skyline Chili chain of chili restaurants based in Cincinnati, Ohio.

Lambrinides was born a Greek in Kastoria, then part of the Ottoman Empire, now in Greece. He emigrated to the US in 1912 at age 33.

In 1949, Lambrinides and his three sons opened a small restaurant in the Cincinnati area now known as Price Hill. They named the restaurant Skyline Chili because of its panoramic view of downtown Cincinnati.

Lambrinides and his wife had five sons.

He died in 1962.