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Nevan Krogan

Nevan Krogan
Academic background
EducationUniversity of Regina
University of Toronto
ThesisProtein complexes and epistatic mini-array profiles (E-MAPs) reveal pathways involved in chromatin function (2006)
Doctoral advisorJack Greenblatt
Academic work
InstitutionsUniversity of California San Francisco (UCSF)
J. David Gladstone Institutes

Nevan J. Krogan is a Canadian molecular and systems biologist.[1] He is a professor and the Director of the Quantitative Biosciences Institute (QBI) at the University of California San Francisco (UCSF), as well as a senior investigator at the J. David Gladstone Institutes.[2]

Krogan’s research focuses on developing and using unbiased, quantitative systems approaches to study a wide variety of diseases with the ultimate goal of developing new therapeutics. He has authored over 350 papers in the field of molecular biology and has given over 400 lectures and seminars around the world.

Early life and education

Krogan was born in Regina, Saskatchewan, Canada. He obtained his undergraduate degree in chemistry in 1997 and his M.Sc. in biology in 1999 from the University of Regina. Krogan received his Ph.D. in medical genetics at the University of Toronto in 2006 with Jack Greenblatt as his doctoral advisor. During his PhD, he explored the combination of protein-protein and genetic interaction data sets.[3][4]

Career

Krogan became a Sandler Fellow in 2006 at UCSF, an assistant professor in 2007, and a full professor in 2011. He also became an investigator at the Gladstone Institutes in 2011.[5] He was appointed director of the Quantitative Biosciences Institutes at UCSF in March 2016.[6]

Krogan serves as Director of The HARC Center, an NIH-funded collaborative group that focuses on the structural characterization of HIV-human protein complexes. Krogan is also the co-Director of three Cell Mapping initiatives, the Cancer Cell Mapping Initiative (CCMI),[7] the Host Pathogen Map Initiative (HPMI)[8] and the Psychiatric Cell Map Initiative (PCMI).[9] These initiatives map the gene and protein networks in healthy and diseased cells with these maps being used to better understand disease and provide novel therapies to fight them.

In 2020, Krogan led the work to create the SARS-CoV-2 interactome and assembled the QBI Coronavirus Research Group (QCRG) to study SARS-CoV-2 and to find treatments for Covid-19.[10]

Krogan co-established the Institut Pasteur-UCSF Quantitative Biosciences Institute (QBI) Center of Excellence in Emerging Infectious Diseases, a partnership between the University of California, San Francisco (UCSF), and the Institut Pasteur in Paris, France.[11] The Center focuses on pandemic preparedness as well as the prediction and treatment of emerging infectious diseases.[12][13]

In 2022, Krogan co-founded Rezo Therapeutics, a biotechnology company focused on the integrated mapping of disease networks for precision therapeutics.[14] Rezo Therapeutics is located in the Bay Area and is based on technology from QBI at UCSF.[15]

Philanthropy

In 2021, Krogan contributed $2.08 million to the University of Regina, the largest donation in the university’s history, in order to help ten Haitian students attend post-secondary in Regina. For this, he has worked alongside the Children of Haiti Project.[16]

Awards and honors

  • 2004 – Hannah Farkas-Himsley and Alexander Memorial Award[17]
  • 2005 – L. W. Macpherson Microbiology Award[18]
  • 2008 – Top 25 authors of high-impact papers in molecular biology and genetics from 2002 to 2006[19]
  • 2009-2012 – Searle Scholar, Searle Foundation[20]
  • 2009-2014 – Keck Distinguished Young Scholar, W. M. Keck Foundation[21]
  • 2017 – The Roddenberry Prize, Roddenberry Foundation[22]
  • 2020 – Excellence in Research Award from the Laboratory of Genomics Research (LGR)[23]
  • 2020, 2022 – Clarivate Web of Science, Highly Cited Researchers - ranked in top 1% of citations for field and year[22]
  • 2021 – France Legion of Honor, decreed by the President of the French Republic[24]
  • 2022 – Elected to EMBO (European Molecular Biology Organization)[25][26]
  • 2022 – Louis Pasteur Medal 2022[27]
  • 2023 – Research!America Discovery | Innovation | Health Prize[28]

References

  1. ^ "Krogan Lab". kroganlab.ucsf.edu. Retrieved 8 January 2018.
  2. ^ "UCSF Establishes Quantitative Biosciences Institute". UC San Francisco. Retrieved 2017-02-01.
  3. ^ Schuldiner, Maya; Collins, Sean R.; Thompson, Natalie J.; Denic, Vladimir; Bhamidipati, Arunashree; Punna, Thanuja; Ihmels, Jan; Andrews, Brenda; Boone, Charles; Greenblatt, Jack F.; Weissman, Jonathan S.; Krogan, Nevan J. (2005-11-04). "Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile". Cell. 123 (3): 507–519. doi:10.1016/j.cell.2005.08.031. ISSN 0092-8674. PMID 16269340. S2CID 5686200.
  4. ^ Collins, Sean R.; Miller, Kyle M.; Maas, Nancy L.; Roguev, Assen; Fillingham, Jeffrey; Chu, Clement S.; Schuldiner, Maya; Gebbia, Marinella; Recht, Judith; Shales, Michael; Ding, Huiming; Xu, Hong; Han, Junhong; Ingvarsdottir, Kristin; Cheng, Benjamin; Andrews, Brenda; Boone, Charles; Berger, Shelley L.; Hieter, Phil; Zhang, Zhiguo; Brown, Grant W.; Ingles, C. James; Emili, Andrew; Allis, C. David; Toczyski, David P.; Weissman, Jonathan S.; Greenblatt, Jack F.; Krogan, Nevan J. (2007-04-12). "Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map". Nature. 446 (7137): 806–810. Bibcode:2007Natur.446..806C. doi:10.1038/nature05649. ISSN 1476-4687. PMID 17314980. S2CID 4419709.
  5. ^ "Krogan Lab". kroganlab.ucsf.edu. Retrieved 8 January 2018.
  6. ^ "Thermo Fisher Scientific Proteomics Facility for Disease Target Discovery Opens at Gladstone Institutes". gladstone.org. Retrieved 23 June 2015.
  7. ^ Krogan, N. J.; Lippman, S.; Agard, D. A.; Ashworth, A.; Ideker, T. (2015). "The cancer cell map initiative: defining the hallmark networks of cancer". Molecular Cell. 58 (4): 690–698. doi:10.1016/j.molcel.2015.05.008. PMC 5359018. PMID 26000852.
  8. ^ "HPMI - About". ucsf.edu. Retrieved 22 June 2017.
  9. ^ "PCMI - About". ucsf.edu. Retrieved 22 June 2017.
  10. ^ Gordon, D. E.; et al. (2020). "A SARS-CoV-2 protein interaction map reveals targets for drug repurposing". Nature. 583 (7816): 459–468. doi:10.1038/s41586-020-2286-9. PMC 7431030. PMID 32353859.
  11. ^ "Collaboration with UCSF QBI: Institut Pasteur establishes presence in USA". Institut Pasteur. 2023-02-22. Retrieved 2023-10-06.
  12. ^ "Institut Pasteur advancing COVID-19 research – Global research collaboration for infectious disease preparednessGLOPID-R". www.glopid-r.org. Retrieved 2023-10-06.
  13. ^ "International Pasteurian Research Program in Response to Coronavirus in Africa (REPAIR) | Pasteur Network". pasteur-network.org. Retrieved 2023-10-06.
  14. ^ "Rezo, Founded by Renowned UCSF Scientists, Launches with $78 Million". Innovation Ventures. Retrieved 2023-10-06.
  15. ^ "The Funded: A pair of $75M rounds tops recent Bay Area venture deals". www.bizjournals.com. Retrieved 2023-10-06.
  16. ^ Stein, Logan. "Alumni makes largest donation in University of Regina's history". 980 CJME. Retrieved 2021-10-03.
  17. ^ "Gladstone Scientists Honored as Finalists for the Blavatnik Awards". gladstone.org. Retrieved 1 June 2016.
  18. ^ "Gladstone Scientists Honored as Finalists for the Blavatnik Awards". gladstone.org. Retrieved 1 June 2016.
  19. ^ "Sequencing Biology's Hottest, 2002-06".
  20. ^ "Searle Scholars Program : Nevan J. Krogan (2009)". www.searlescholars.net. Retrieved 2017-02-01.
  21. ^ "Nevan Krogan, "Using Systems Approaches to Study Disease"". biology.stanford.edu. Retrieved 4 April 2016.
  22. ^ a b "Nevan Krogan, PhD". ucsf.edu. Retrieved 4 February 2017.
  23. ^ "LGR Awards Seed Funding to COVID-19 Projects at UC Berkeley and UCSF". Innovative Genomics Institute (IGI). Retrieved 2023-10-06.
  24. ^ "Nevan Krogan, PhD, director UCSF's Quantitative Biosciences Institute (QBI) and founder of QBI's Coronavirus Research Group (QCRG), has been awarded the Legion of Honor, France's highest honor, in a ceremony in Paris". www.ucsf.edu. 2022-10-27. Retrieved 2023-10-06.
  25. ^ "EMBO elects 67 new members and associate members – Press releases – EMBO". 2022-07-06. Retrieved 2023-10-06.
  26. ^ "Krogan elected to the European Molecular Biology Organization". UCSF School of Pharmacy. 2022-07-11. Retrieved 2023-10-06.
  27. ^ "Team | rezo". rezotx.com. Retrieved 2023-10-06.
  28. ^ "Nevan Krogan Named First-Ever Winner of the Discovery | Innovation | Health Prize". Research!America. 2023-09-20. Retrieved 2023-10-06.
Quelle: https://en.wikipedia.org/wiki/Nevan_Krogan