Nippon Professional Baseball (NPB) is the highest level of professional baseball in Japan.

NPB can also refer to:

• NAS Parallel Benchmarks, a set of benchmarks developed by the NASA for measuring the performance of supercomputers
• National Printing Bureau of Japan
• National Pork Board of the United States
• Nederlandsche Padvinders Bond, one of the scouting organizations that evolved into Scouting Nederland
• Newport Beach a city in Orange County, California, United States
• Nitrate-producing bacteria, also known as nitrifying bacteria in the nitrogen cycle
• Northern Black Polished Ware, a period of South Asian history (c. 700–200 BC)
• Parole Board of Canada, a Canadian government agency
• NPB or n-PB, n-propyl bromide, solvent
• Network packet broker, a network monitoring system