NACC may refer to:

• National Anti-Corruption Commission (Australia)
• National Anti-Corruption Commission (Thailand)
• National Anti-Corruption Commission
• National assessment on climate change, a multidisciplinary effort to study and portray the potential effects of human-induced global warming on the United States
• National Association for Colitis and Crohn's Disease (UK)
• National Association of Catholic Chaplains, a professional association for certified chaplains and clinical pastoral educators
• National Automobile Chamber of Commerce, an early name for the Automobile Manufacturers Association
• North American Christian Convention, an annual meeting of ministers and other active leaders in the Independent Christian Churches/Churches of Christ
• North American Classification Committee, see American Ornithological Society § Committees
• North American College and Community Radio Chart, a weekly top 200 radio chart tracking college radio in North America
• North American Competitiveness Council, an official tri-national working group of the Security and Prosperity Partnership of North America
• North Atlantic Cooperation Council, the precursor to the Euro-Atlantic Partnership Council
• Northeast Alabama Community College, a two-year community college on the border of Jackson and DeKalb Counties
• Northern Athletics Collegiate Conference, a conference competing in NCAA Division III in the Upper Midwest
• Nucleus accumbens (NAcc), a brain structure