Mysterium may refer to:

• Mysterium (John Zorn album), 2005
• Mysterium (Manilla Road album), 2013
• Mysterium (board game), a cooperative board game designed by Oleksandr Nevskiy and Oleg Sidorenko
• Mysterium (novel), an alternate history novel by Robert Charles Wilson
• Mysterium (Scriabin), an unfinished work by the Russian composer Alexander Scriabin
• Mysterium, seventh part of composer Georges Lentz’ musical cycle Caeli enarrant...
• Mysterium (video game), a video game published in 1991
• An annual conference concerned with the Myst series of computer games
• Greco-Roman mysteries, religious schools for which participation was reserved to initiates

• Mysteria (disambiguation)
• Mystery (disambiguation)
• Mysterium fidei (disambiguation)
• All pages with titles containing mysterium