Mudd is a surname. Notable people with the surname include:

• Daniel Mudd (born 1956), American CEO, son of Roger Mudd
• David Mudd (1933–2020), English politician
• Harvey Seeley Mudd (1888–1955), American mining engineer, namesake of Harvey Mudd College
• Henry T. Mudd (1913–1990), American businessman, son of Harvey
• Howard Mudd (1942–2020), American football player and coach
• Jane Mudd (born 1968), Welsh politician
• Jodie Mudd (born 1960), American golfer
• Richard Mudd (1901–2002), grandson of Samuel
• Robert H. Mudd (1875–1904), American football player and coach
• Roger Mudd (1928–2021), American television journalist
• Samuel Mudd (1833–1883), American physician who set John Wilkes Booth's broken leg
• Seeley G. Mudd (1895–1968), California physician
• Seeley W. Mudd (1861–1926), American mining engineer, father of Harvey and Seeley G.
• Stuart Mudd (1893–1975), American physician and microbiologist
• William Mudd (1830–1879), British lichenologist

• Harry Mudd, who appears in Star Trek: The Original Series and Star Trek: The Animated Series
• Lt. Mudd, in Joseph Heller's novel Catch-22
• Millicent Mudd, in the webcomic Ozy and Millie

• Mudd Club
• Harvey Mudd College
• Puddle of Mudd, American band
• "Mr. Mudd and Mr. Gold", a song by Townes Van Zandt
• Mud (disambiguation)