Muzhou or Mu Prefecture (睦州) was a zhou (prefecture) in imperial China centering on modern Jiande, Zhejiang, China. It existed (intermittently) from 603 to 1121, when its name changed to Yanzhou (and eventually to Yanzhou Prefecture in the Ming dynasty).

The administrative region of Muzhou in the Tang dynasty falls within modern Jiande in western Zhejiang. It probably includes modern:

• Jiande
• Tonglu County
• Chun'an County

• Yanzhou Prefecture

• Shi Weile, ed. (2005). Zhongguo Lishi Diming Da Cidian (中国历史地名大词典) [Large Dictionary of Chinese Historical Place Names] (in Chinese). China Social Sciences Press. p. 2689. ISBN 7-5004-4929-1.