Paul Morphy was an American chess player, considered an unofficial world champion in the late 1850s.

Morphy may also refer to:

• Alonzo Morphy (1798–1856), American lawyer, Attorney General of Louisiana
• Countess Morphy (1883–1938), nom de plume of British-American author Marcelle Azra Hincks
• Donal Morphy (1900–1975), British electrical engineer
• Florence Morphy (c. 1860–1944), Australian-born Countess of Darnley
• Garret Morphy (c. 1655–c. 1716), Irish painter
• George Morphy (1884–1946), Irish athlete
• Guillermo Morphy (1836–1899), Spanish aristocrat, musicologist and composer
• Harold Morphy (1902–1987), British rower
• Howard Morphy (born 1947), British anthropologist
• Hugh Boulton Morphy (1860–1932), Canadian politician

• Morphe Cosmetics, American cosmetic retailer
• Morphine, pain medication of the opiate family