Morehouse is a surname. Notable people with the surname include:

• Albert P. Morehouse (1835–1891), 26th Governor of Missouri
• Daniel Walter Morehouse (1876–1941) Astronomer and president of Drake University
• David Morehouse (born 1960), President and Chief Executive Officer of Pittsburgh Penguins of the National Hockey League
• Henry Lyman Morehouse (1834–1917), American Baptist minister and hymn author
• Jim Morehouse (1864–1914), Australian rules footballer
• Lyda Morehouse (born 1967), American science fiction and fantasy author
• Oscar E. Morehouse (1857–1935), Canadian politician and doctor
• Tim Morehouse (born 1978), American fencer
• Ward Morehouse (1895–1966), American theater critic, newspaper columnist, playwright and author
• Ward Morehouse (activist) (1929–2012), anti-corporate activist

• Moorehouse (surname)
• Moorhouse (surname)