Mir Sher Muhammad Talpur
Mir Sher Muhammad Talpur and his Attendant
3rd Mir of Mirpur Khas
Reign	1829 – 24 March 1843
Predecessor	Ali Murad Khan Talpur
Successor	Position abolished
Born	1810 Mirpur Khas, Sind State
Died	August 24, 1874(1874-08-24) (aged 63–64)
House	Manikani
Dynasty	Talpur
Father	Ali Murad Khan Talpur

Mir Sher Muhammad Talpur was the last Mir of Mirpur Khas who belonged to the Manikani house of the royal Talpur dynasty. The son of Mir Ali Murad Talpur, the founder of Mirpur Khas, he took up the throne in 1829 and held onto it until he was defeated in the Battle of Hyderabad in 1843.

After becoming ruler of the Talpur dynasty, his reign saw a conflict with the British East India Company, who launched an invasion of the province of Sindh under the auspices of General Charles James Napier, aiming to annex the entire region. On 24 March 1843, troops under his command fought against a Company force in the Battle of Hyderabad; the British emerged victorious, and captured the city of Hyderabad soon after. Talpur then retreated into the countryside, where forces loyal to him and equipped largely with muskets waged a guerrilla campaign against the British, whose efforts to counter this led Napier to coin the word "counterinsurgency". He eventually died on 24 August 1874.^{[citation needed]}

• Talpur, Parveen (2002). Talpur Rule in Sindh. Karachi, Pakistan: Ferozsons. ISBN 978-9690017574.
• Pathan, Mumtaz Husain (2017). Talpurs in Sindh, 1783-1843. Karachi, Pakistan: Endowment Fund Trust for Preservation of the Heritage of Sindh. ISBN 978-9699860119.

• " "Sher-i-Sindh" by Mir Atta Muhammad Talpur"
• "Mir Sher Muhammad Khan Mankani" by Mir Muhammad Bukhsh Khan Talpur