Michelle Adair Ozbun (born February 16, 1965) is an American molecular virologist who is the Maralyn S. Budke Endowed Professor in Viral Oncology at the University of New Mexico School of Medicine. Her research considers cancer biology and how human papillomavirus infections cause pathology including their contributions to cancers.

Ozbun received an associate of science degree at Mesa College^[1] (now Colorado Mesa University), where she was recognized as a Distinguished Alumnus in 2009.^[2] She was an undergraduate student in microbiology and chemistry at Colorado State University. She completed her PhD in molecular virology under the supervision of Janet S. Butel at the Baylor College of Medicine. She completed a postdoctoral fellowship at Pennsylvania State University College of Medicine in the laboratory of Dr. Craig Meyers.^{[citation needed]}

In 1998, Ozbun was appointed to the faculty at the University of New Mexico, where she holds an endowed chair in viral oncology.^[3] Her research considers papillomaviruses, which are etiologic agents of tumors of the skin. These tumors can be benign (e.g. genital warts, plantar warts) and malignant (e.g. anogenital cancers and cervical carcinomas). Her research looks to understand the replicative cycles of papillomaviruses and their differentiation-dependent replicative cycles through the use of organotypic cell culture. Disruptions to these replicative cycles can result in malignancies. She studies the relationships between human papillomavirus infection and cancer, studying the molecular mechanisms that underpin viral infection, the stages of infection that permit or deny how viral persistence is established.^[4]

Ozbun developed a strategy to measure how many infectious human papillomavirus particles are left on a surface following disinfection.^[5][6]

• C. Meyers; T. J. Mayer; M. A. Ozbun (October 1, 1997). "Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA" (PDF). Journal of Virology. 71 (10): 7381–7386. doi:10.1128/JVI.71.10.7381-7386.1997. ISSN 0022-538X. PMC 192083. PMID 9311816. Wikidata Q35895308.
• Zurab Surviladze; Rosa T Sterk; Sergio A DeHaro; Michelle A Ozbun (December 19, 2012). "Cellular entry of human papillomavirus type 16 involves activation of the phosphatidylinositol 3-kinase/Akt/mTOR pathway and inhibition of autophagy". Journal of Virology. 87 (5): 2508–2517. doi:10.1128/JVI.02319-12. ISSN 0022-538X. PMC 3571372. PMID 23255786. Wikidata Q36607050.
• M A Ozbun; C Meyers (July 1, 1997). "Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b". Journal of Virology. 71 (7): 5161–5172. ISSN 0022-538X. PMC 191751. PMID 9188583. Wikidata Q35888022.

• Elected as a Fellow, American Academy of Microbiology ^[7]

Ozbun is lesbian. She is a member of 500 Queer Scientists.^[8]