Michael Blake may refer to:

• Michael Blake (author) (1945–2015), American author, best known for his film adaptation of his novel Dances with Wolves
• Michael Blake (bishop) (1775–1860), Irish Roman Catholic bishop of Dromore
• Michael Blake (composer) (born 1951), South African contemporary classical music composer
• Michael Blake (musician) (born 1964), Canadian musician
• Michael Blake (politician) (born 1982), New York Assembly member
• Michael Blake (rugby league) (born 1961), Australian former rugby league footballer
• Michael F. Blake (1857–1929), judge in New York City
• Mick Blake (1874–1931), Australian rules footballer
• Mike Blake, character in Alabama Moon

• Blake (surname)
• Blake Michael (born 1996), American actor