Metis or Métis, meaning "mixed" in French, may refer to:

• Métis, recognized Indigenous communities in Canada and the United States whose distinct culture and language emerged after early intermarriage between First Nations peoples and early European settlers, primarily French fur trappers

• Grand-Métis, Quebec, Canada
• Métis-sur-Mer, Quebec, Canada
• Saint-Paul-des-Métis, now St. Paul, Alberta, Canada
• Metis Shoal, the tip of a submarine volcano in Tonga
• Metiş, a village in Mihăileni, Sibiu, Romania
• Metis Island in Antarctica

• 9 Metis, an asteroid
• 9K115 Metis, a Russian anti–tank missile system
• 9K115-2 Metis-M, a Russian anti–tank missile system
• Metis (American musician) (fl. 21st century), American rapper
• Metis (theorem prover), an automated theorem prover
• Metis (Japanese musician) (born 1984), Japanese reggae singer
• Metis (moon), the innermost and fastest-moving of Jupiter's known moons
• Metis (mythology), an Oceanid and the first wife of Zeus
• Metis (software), business modeling software
• Metis (software), integrated cloud-based system provided by Oracle for Home Office
• METIS, a software package for graph partitioning
• METIS, an instrument planned to be installed in the Extremely Large Telescope
• Metis TransPacific Airlines, a Canadian airline based in Vancouver
• Metis (holothurian), or Actinopyga, a genus of sea cucumbers
• Metis (Character), a playable character from Persona 3 FES

• Metisse, windowing software
• Metius, Dutch geometer
• Metius (crater), a lunar impact crater
• All pages with titles beginning with Metis
• All pages with titles containing Metis
• Meti (disambiguation)
• Mestizo