Hip hop recording artists Method Man and Redman move into a predominantly white suburb in New Jersey (along with Method Man's mother Dorothea, and two friends Lil Bit and Dupree). When the pair violates neighborhood association rules from throwing a wild party and face eviction, they attempt to use kindness (and fruitcake) to endear themselves to their new neighbors. In particular, they meet their family neighbors the Blafords: Nancy (whom they call "Neighbor Lady" throughout the whole series instead of Nancy), her husband Bill and their son Skyler.

Concerned that magazine writer Keith Debeetham (Dale Godboldo) will portray them as "soft" (which he previously did to 50 Cent) now that they live in the suburbs, Method and Red grill Keith every chance they get so that he knows that they are "still hood". At the same time, Meth and Red promised Skyler that they will appear at his birthday party and he tells everyone at his school. Lil Bit warns Meth and Red that they won't "look too hood, sitting there eating birthday cake, with a bunch of White suburban kids". On top of that, Keith Debeetham reveals one reason he gave 50 Cent a bad review is because he still lives with his mother. The pair have to find a way to 1. Not let Keith know that Dorthy is Meth's mom. 2. Attend Skyler's party. 3. Convince Keith that they have not changed since moving to the suburbs.

As Dorothea's 25th anniversary at work approaches, Redman promises to get Chaka Khan to perform at her party. Meanwhile, Nancy is blasting her Kenny Loggins music from her house which angers Meth because he has a personal grudge against Kenny. While setting up for the party, Meth and Red suck up all the power from the neighborhood for their own home. Nancy calls electric company agents and they shut Meth's and Red power off. Meth must find a way to get the power back on in time for his Mom's party. Singers Chaka Khan and Kenny Loggins appear as themselves.

Dorthy is caring for a cherry tree of hers which she has kept since their old neighborhood, but Nancy tells her that there is a neighborhood law that states "exotics are prohibited" and that her tree will be cut down .Method and Red go to a personal lawyer and ask about the law to which there are told they could have changed the law a month ago when it was their turn to become Neighborhood Association Presidents (a rotating one month position that lets a homeowner do what they please). It is revealed that Nancy did not tell Meth and Red about it purposely because she does not want them to be presidents. Meth and Red gain the position anyway and soon become power hungry and perform many crazy activities and have several fun moments.....everything except changing the law concerning Dorthy's tree.

Method and Red seek to build a sports arena (the Methodome at the Redowlands) before NBA basketball star Yao Ming whom they are rivals with because Red caused Yao an injury in the past. Nancy's husband Bill is a businessman, so red asks him does he know any investors that can help pay for the $500 million stadium. Bill tells them of an investor named Carrie Norris (Carmen Electra). Dorothea forces Meth to have a talk with Skyler after the boy is unduly influenced by one of his music videos. Meth goes to Skyler's school and talks to the principal but ends up slapping her on the behind which causes everyone at the school to start doing it. Meth is now viewed as a negative influence across the nation. Meth and Red must now clear Meth's image and try to get the money for the stadium.

Method and Red pit Nancy and Bill Blaford against each other as a part of a plan to use the Blafords' porch for their Miss Ghetto USA beauty pageant. Nancy immediately says no, but Bill says yes after Meth and Red go to him afterwards. Nancy gets furious with Bill for this and kicks him out, so he stays with Meth and Red. When the ladies arrive for the pageant, Bill suddenly starts to get on everyone's nerves (bugging Dorthy while she's watching a soap opera. throwing out Meth's marijuana, and stopping Red from getting any sexual action with the women). The guys must decide if they want to throw Bill out or keep him in the house until the pageant is over, but their patience is very low.

Method Man falls hard for Brenda Biscoe (Elise Neal) Bill 's attractive co-worker and the mother of Skyler's love interest Morgan. She rejects him at first but starts to get attracted after he lies and says he hikes and goes to church (two of Brenda's hobbies). Red bets Meth that if he doesn't get with Brenda then he has to buy Red a new car. Meth eventually starts to fall for Brenda and vice versa ,to the disgust of Nancy who knows Brenda as well. Red and Dorthy then conspire a plan to get rid of Brenda as Meth starts spending way more time with Brenda than with them two.

Lil Bit and Dupree invite the circus to Meth and Red's home without their permission. Meth orders them to get the circus away but suddenly a rash of burglaries strikes the neighborhood. Nancy forms a neighborhood watch and finds herself patrolling with Method Man. Red's addiction to video games weakens his eyesight and he spends most of his time sexually cuddling with his partner instead of looking for the burglar. Meth and Nancy end up bickering with each other when Meth and Red accuse Nancy's son Skylar of being the burglar. They both have to put their differences aside so that no more robberies would occur.

Method and Red try to keep an old friend in prison (Charles Chesterfield Hillfont/Chu Chu) from finding out about his girlfriend Rose's new line of work. Chu Chu asked Meth and Red to look out for his girlfriend while he is locked up but both of them have forgotten about her for years. They invite her to stay at their house until Chu Chu gets out. Meanwhile,Dorthy forces the boys to help Skyler build a car for the soap box derby. Meth and Red try their best to avoid Skyler because they have been trying to get away from Skyler since meeting him and not spend time with him. Meth and Red bribe him with hundreds of dollars to leave them alone every time he comes over and asks for their help with the car. Now the boys have to take care of Rose and get Skyler to leave them alone.

Rival hip-hop artist Fear (Fredro Starr) moves into a better gated community and lures Method and Red's ace TV repairman away from them, so the duo challenges him to a neighborhood basketball game. NBA basketball players Devean George and Corey Maggette appears as themselves.

Dorothea opens a hair salon in the game room. An expensive diamond necklace that Red borrowed from a German jeweler goes missing.

No longer able to stand Dorothea's constant nagging, Red buys his own mansion in Nottingshire Estates, just as Nancy tries to become "Real Estate Agent of the Year." Tommy Chong appears as himself.

Method Man's theme park Methodome opens.