Matt or Matthew Hughes may refer to:

• Matt Hughes (fighter) (born 1973), American professional mixed martial artist
• Matt Hughes (rower) (born 1981), American Olympic rower
• Matt Hughes (writer) (born 1949), Canadian science fiction writer
• Matthew Hughes (badminton) (born 1978), Welsh badminton player
• Matthew Hughes (cricketer) (born 1996), English cricketer
• Matthew Hughes (politician) (born 1950), Western Australian state politician
• Matthew Hughes (runner) (born 1989), Canadian athlete
• Matt Hughes (died 2010), meteorologist, storm chaser on the TV series Storm Chasers

• Mathew Hughes (1822–1882), Victoria Cross recipient
• Hughes (surname)