Masiello is a surname originating in Italy. Notable people with the surname include:

• Andrea Masiello (born 1986), Italian soccer player
• Anthony Masiello, Buffalo, New York, politician
• Luciano Masiello (born 1952), Italian-born English and Irish soccer player
• Salvatore Masiello (born 1982), Italian soccer player
• Wendy M. Masiello, United States Air Force officer