Mark Simmons may refer to:

• Mark Simmons (American football) (born 1984), American football wide receiver
• Mark Simmons (comedian) (born 1984 or 1985), British comedian
• Mark Simmons (cricketer) (born 1955), former English cricketer
• Mark Simmons (boxer) (born 1974), Canadian heavyweight boxer
• Mark Simmons (police officer), British senior police officer
• Mark Simmons (politician), former Oregon house of representatives member
• Mark Simmons (discus thrower) (born 1978), American discus thrower, All-American for the SMU Mustangs track and field team

• Marc Simmons, American historian
• Marcus Simmons (disambiguation)