Margaret Smith or Maggie Smith may refer to:

• Margaret Smith Court, known as Margaret Court (born 1942), Australian tennis player
• Margaret A. Smith, superintendent of Volusia County Schools
• Margaret Bayard Smith (1778–1844), American author
• Margaret Charles Smith (1906–2004), African-American midwife
• Margaret Chase Smith (1897–1995), United States Senator from Maine
• Margaret Gladys Smith (1896–1970), American pathologist
• Maggie Gordon-Smith, British track cyclist
• Margaret Keiver Smith (1856–1934), American psychological and educational researcher
• Margaret Mary Smith (1916–1986), ichthyologist, fish illustrator and academic
• Maggie Rainey-Smith (born 1950), New Zealand writer
• Margaret Smith (author) (1884–1970), wrote Muslim Women Mystics
• Maggie Smith (1934–2024), British actress
• Margaret Smith (Scottish politician) (born 1961), Liberal Democrat Member of the Scottish Parliament for Edinburgh West
• Margaret Smith (West Virginia politician) (born 1952), member of the West Virginia House of Delegates
• Maggie Smith (ceramist) (born 1950), American artist
• Margaret Smith (poet) (born 1958), American poet and artist
• Maggie Smith (poet) (born 1977), American writer
• Margaret Smith (bodybuilder) (born 1979), American professional female bodybuilder
• Margaret Smith (comedian), American standup comic, actress, writer and producer
• Margaret Taylor (born Margaret Mackall Smith, 1788-1852), former first lady of the United States
• Margaret Taylor Smith, American author and social activist
• Margaret Smith, a character from Regular Show

• MV Margaret Smith, Empire ship originally named Empire Reaper

• Marguerite Smith (disambiguation)