Marco Rodriguez may refer to:

• Marco Rodríguez (actor) (born 1953), Hispanic-American actor
• Marco Antonio Rodríguez (born 1973), Mexican football referee
• Marco Antonio Rodríguez (racewalker) (born 1994), Bolivian racewalker
• Marco Rodrigues, previously known as Khushnood Butt outside Japan, a video game character from the Fatal Fury series
• Marco Rodríguez (footballer), El Salvadorian football player for A.D. Chalatenango