Protein-coding gene in the species Homo sapiens
For mammalian sterile 20–like kinase-1, see
STK4 .
Macrophage-stimulating protein (MSP ), also known as hepatocyte growth factor-like protein (HLP , HGFL , or HGFLP ), is a protein that in humans is encoded by the MST1 (macrophage-stimulating 1 ) gene .[ 5] [ 6] [ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000173531 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032591 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Gerber MJ, Drabkin HA, Firnhaber C, Miller YE, Scoggin CH, Smith DI (Oct 1988). "Regional localization of chromosome 3-specific DNA fragments by using a hybrid cell deletion mapping panel" . Am J Hum Genet . 43 (4): 442–51. PMC 1715492 PMID 2902784 . ^ Yoshimura T, Yuhki N, Wang MH, Skeel A, Leonard EJ (Aug 1993). "Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3" . J Biol Chem . 268 (21): 15461–8. doi :10.1016/S0021-9258(18)82279-7 PMID 8393443 . ^ "Entrez Gene: MST1 macrophage stimulating 1 (hepatocyte growth factor-like)" .
Further reading
Han S, Stuart LA, Degen SJ (1991). "Characterization of the DNF15S2 locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry . 30 (40): 9768–80. doi :10.1021/bi00104a029 . PMID 1655021 . Skeel A, Yoshimura T, Showalter SD, et al. (1991). "Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity" . J. Exp. Med . 173 (5): 1227–34. doi :10.1084/jem.173.5.1227 . PMC 2118857 PMID 1827141 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Waltz SE, Gould FK, Air EL, et al. (1996). "Hepatocyte nuclear factor-4 is responsible for the liver-specific expression of the gene coding for hepatocyte growth factor-like protein" . J. Biol. Chem . 271 (15): 9024–32. doi :10.1074/jbc.271.15.9024 PMID 8621550 . Creasy CL, Ambrose DM, Chernoff J (1996). "The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain" . J. Biol. Chem . 271 (35): 21049–53. doi :10.1074/jbc.271.35.21049 PMID 8702870 . Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility" . J. Clin. Invest . 99 (4): 701–9. doi :10.1172/JCI119214 . PMC 507853 PMID 9045873 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Yoshikawa W, Hara H, Takehara T, et al. (1999). "Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein" . Arch. Biochem. Biophys . 363 (2): 356–60. doi :10.1006/abbi.1998.1090 . PMID 10068459 . Degen SJ, McDowell SA, Waltz SE, et al. (2000). "Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein". DNA Seq . 8 (6): 409–13. doi :10.3109/10425179809020903 . PMID 10728827 . Skeel A, Leonard EJ (2001). "alpha 1-Antichymotrypsin is the human plasma inhibitor of macrophage ectoenzymes that cleave pro-macrophage stimulating protein" . J. Biol. Chem . 276 (24): 21932–7. doi :10.1074/jbc.M100652200 PMID 11274154 . Rampino T, Collesi C, Gregorini M, et al. (2002). "Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells" . J. Am. Soc. Nephrol . 13 (3): 649–57. doi :10.1681/ASN.V133649 PMID 11856768 . Zhou YQ, Chen YQ, Fisher JH, Wang MH (2002). "Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages" . J. Biol. Chem . 277 (41): 38104–10. doi :10.1074/jbc.M206167200 PMID 12177064 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration" . Dev. Cell . 5 (2): 257–71. doi :10.1016/S1534-5807(03)00201-6 PMID 12919677 . Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation" . J. Biol. Chem . 279 (5): 3726–32. doi :10.1074/jbc.M309342200 PMID 14597639 . Matsuzaki S, Canis M, Pouly JL, et al. (2005). "The macrophage stimulating protein/RON system: a potential novel target for prevention and treatment of endometriosis" . Mol. Hum. Reprod . 11 (5): 345–9. doi :10.1093/molehr/gah162 PMID 15764806 . Zalcenstein A, Weisz L, Stambolsky P, et al. (2006). "Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53" . Oncogene . 25 (3): 359–69. doi :10.1038/sj.onc.1209061 PMID 16170349 . Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . J. Proteome Res . 4 (6): 2070–80. doi :10.1021/pr0502065 . PMC 1850943 PMID 16335952 .
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See IL-28R (IFNLR) here instead.
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