Macomber may refer to:

• A. Kingsley Macomber (1874–1955), American adventurer, businessman, horse owner and breeder
• Bart Macomber (1894–1971), American college football player
• Debbie Macomber (b. 1948), American author of romance novels
• Eleanor Macomber (1801–1840), American missionary, teacher
• Harold M. Macomber (1914–2002), American politician in Maine
• John D. Macomber (b. 1928), American banker
• John R. Macomber (1875–1955), American financier and sportsman
• Joshua Mason Macomber (1811–1881), American educator and physician
• Mary Lizzie Macomber (1861–1916), American artist
• Stanley Macomber (1887–1967), American inventor
• William B. Macomber Jr. (1921–2003), American diplomat

• Macomber, West Virginia, an unincorporated community in Preston County
• Macomber Mountain, a summit located in Adirondack Mountains of New York
• Macomber Reservation, conservation land in Framingham, Massachusetts, once part of the Raceland estate

• Calvin T. Macomber House, a historic house in Bristol County, Massachusetts
• Macomber Stone House, a historic home located in Schenectady County, New York

• Eisner v. Macomber, a 1920 decision by the United States Supreme Court
• The Macomber Affair, a 1947 American adventure drama film based on the below Hemingway short story
• Macomber High School (Toledo, Ohio) a former public vocational school in Toledo, Ohio
• "The Short Happy Life of Francis Macomber", a short story by Ernest Hemingway published in 1936

• All pages with titles containing Macomber