MacLeish is a Scottish surname and may refer to:

• Andrew MacLeish (1838–1928), Scottish-American merchant; father of Archibald MacLeish
• Archibald MacLeish (1892–1982), American poet, writer, and Librarian of Congress; Pulitzer Prize winner
• Kenneth MacLeish (1894–1918), American naval aviator; Navy Cross winner
• Rick MacLeish (1950–2016), Canadian ice hockey player

• Peter MacLeish and Beth MacLeish, characters in the TV series, Designated Survivor
• USS MacLeish (DD-220), U.S. Navy Clemson-class destroyer 1920–1946

• McLeish (disambiguation)