MSK may refer to the following:

• Marinestosstruppkompanie, German naval assault troops
• Marske railway station, England, National Rail station code
• Medullary sponge kidney
• Medvedev–Sponheuer–Karnik scale, a macroseismic intensity scale
• Memorial Sloan Kettering Cancer Center
• Minimum-shift keying radio modulation
• Mohammad Sidique Khan, a perpetrator of the July 2005 London bombings
• Moscow
• Moscow Time
• Common abbreviation for Human musculoskeletal system
• Museum of Fine Arts, Ghent (Museum voor Schone Kunsten), Belgium
• Premier Sports, UK TV channel, formerly MSK
• MSK (professional wrestling), a professional wrestling tag team