MSFS may refer to:

• Microsoft Flight Simulator, a series of flight simulator video games.
  • Microsoft Flight Simulator (2020 video game), the 2020 edition of the series.
• Missionaries of St. Francis de Sales, a Catholic religious group

• Master of Science in Financial Services, such as from the American College of Financial Services, Bryn Mawr, Pennsylvania
• Master of Science in Foreign Service, in international affairs, such as from the Walsh School of Foreign Service, Georgetown University, Washington D.C.
• Master of Science in Forensic Science, such as from the John Jay College of Criminal Justice at City University of New York
• Master of Science in Financial Management and Information Systems, such as from the University of Maryland University College