MC2 may refer to:

• Maison de la Culture de Grenoble, a venue for performances in Grenoble, France
• Marvel Comics 2 is an imprint from Marvel Comics whose comic books depict an alternative future timeline for the Marvel Universe
• E = mc² is the equation for mass-energy equivalence
• Microids, a French software company formerly known as MC2-Microïds and later just MC2
• MC2, an alternate symbol for ACTH receptor
• Midnight Club 2 a street racing game released in 2003.
• Project Mc2

• E=MC2 (disambiguation)
• MCMC (disambiguation)
• MCC (disambiguation)
• MC (disambiguation)