Luther Johnson may refer to:

• Luther Alexander Johnson (1875–1965), American politician
• Luther Johnson (racing driver) (1903–1978), American racecar driver
• Luther Johnson (Guitar Junior) (1939–2022), American Chicago blues singer and guitarist
• Luther "Georgia Boy" Johnson (1934–1976), American Chicago blues guitarist and singer
• Luther "Houserocker" Johnson (1939–2019), American electric blues singer, guitarist, and songwriter