Loss Creek may refer to one of several streams:

• Loss Creek (British Columbia), in Capital Regional District, British Columbia

• Loss Creek, in Spring Creek Township, Coffey County, Kansas
• Loss Creek, in Black Wolf Township, Ellsworth County, Kansas
• Loss Creek, a river in Ohio
• Loss Creek, a tributary of the Hiwassee River in Polk County, Tennessee
• Loss Creek (Texas), in Coleman County, Texas

• Lost Creek (disambiguation)