Locust Grove is the name of a number of places in the United States of America:

• Locust Grove, Arkansas

• Locust Grove, Georgia

• Locust Grove, Warren County, Indiana (extinct)
• Locust Grove, Wayne County, Indiana

• Locust Grove, Clark County, Kentucky
• Locust Grove, Pendleton County, Kentucky
• Historic Locust Grove, near Louisville, Kentucky

• Locust Grove (La Plata, Maryland), listed on the NRHP in Charles County, Maryland
• five places named Locust Grove:
  • two places in Garrett County, Maryland
  • in Kent County, Maryland
  • in Allegany County, Maryland
  • in Washington County, Maryland

• Locust Grove, New Jersey

• Locust Grove, New York (a section of Syosset, New York):
• Locust Grove (Poughkeepsie, New York), listed on the NRHP in Dutchess County, New York, also known as Samuel F. B. Morse House

• Locust Grove (Ingleside, North Carolina), listed on the NRHP in North Carolina

• Locust Grove, Adams County, Ohio
• Locust Grove, Licking County, Ohio
• Locust Grove, Mahoning County, Ohio

• Locust Grove, Oklahoma

• Locust Grove, Oregon, a ghost town

• Locust Grove (Bainbridge, Pennsylvania), listed on the NRHP in Pennsylvania
• Locust Grove, Pennsylvania (four places):
  • in Centre County
  • in Lancaster County
  • in Snyder County
  • in York County

• Locust Grove, Tennessee
• Locust Grove (Castalian Springs, Tennessee), listed on the NRHP in Tennessee

• Locust Grove (Jonesville, Texas)

• Locust Grove (Amicus, Virginia), listed on the NRHP in Virginia
• Locust Grove (Dillwyn, Virginia), listed on the NRHP in Virginia
• Locust Grove (Charlottesville, Virginia), listed on the NRHP in Virginia
• Locust Grove (Lynchburg, Virginia), listed on the NRHP in Virginia
• Locust Grove, Orange County, Virginia
• Locust Grove (Page County, Virginia), a historic house
• Locust Grove (Purcellville, Virginia), listed on the NRHP in Virginia
• Locust Grove (Rapidan, Virginia), listed on the NRHP in Virginia