Little Girl Lost may refer to:

• "Little Girl Lost" (The Twilight Zone), an episode of the television series The Twilight Zone
• "Little Girl Lost", an episode of the TV series Mannix
• "Little Girl Lost", an episode of the TV series Bonanza
• "Little Girl Lost", an episode of the TV series Wagon Train
• "Little Girl Lost", an episode of the television series Cold Case Files
• "Little Girl Lost", an episode segment of the series Night Gallery, based on Tubb's short story below
• "Little Girl Lost", an episode of the television series The Inside
• "Little Girl Lost", an episode of the television series Superman: The Animated Series
• Little Girl Lost (film), a 1988 television movie
• Little Girl Lost: The Delimar Vera Story, a 2008 television movie

• "Little Girl Lost", a 1972 song by Kris Kristofferson from the album Border Lord

• "Little Girl Lost", a short science fiction story by Edwin Charles Tubb
• Little Girl Lost, the debut novel by Richard Aleas (pseudonym of Charles Ardai)
• "A Little Girl Lost", a 1794 poem by William Blake
• "The Little Girl Lost", another 1794 poem by William Blake
• Little Girl Lost, an autobiography by American actress Drew Barrymore