The following lists the number one best-selling singles in Canada in 2006 which was published in Billboard magazine under the Hits of the World section.^[1] During January and February of that year, only songs released as physical singles qualified for this chart. During this period, the singles market in Canada was very limited in both scope and availability and, in many cases, these songs received little or no radio support. For tracks other than those by American Idol or Canadian Idol winners, sales were likely to be less than 1,000 per week.

Starting in March, however, Nielsen Entertainment Canada created the Canadian Digital Songs Chart, which tracked sales of digital music downloads, and Billboard stopped publishing the Canadian Singles Chart in favor of the new chart.^[2] Despite this, the physical singles chart continued to be published on Jam!.

These two singles charts were the only ones Canadians had until June 2007, when the Canadian Hot 100 was released to the public. Both also list other big hits in the sales chart.

Note that Billboard publishes charts with an issue date approximately 7–10 days in advance.

Physical singles^[a]

Issue date	Title	Artist(s)	Ref.
January 7	"Alive"	Melissa O'Neill	[3]
January 14	"Hung Up"	Madonna	[4]
January 21			[5]
January 28			[6]
February 4			[7]
February 11			[8]
February 18			[9]
February 25			[10]
March 4			[11]
March 11			[12]
March 18			[13]
March 25			[14]
April 1			[15]
April 8	"Every Day Is Exactly the Same"	Nine Inch Nails	[16]
April 15
April 22			[17]
April 29			[18][b]
May 6
May 13
May 20
May 27	"SOS"	Rihanna
June 3	"Promiscuous"	Nelly Furtado featuring Timbaland
June 10	"Do I Make You Proud"	Taylor Hicks
June 17
June 24
July 1
July 8			[19]
July 15			[20]
July 22			[21]
July 29			[22]
August 5			[23]
August 12			[24]
August 19
August 26
September 2			[25]
September 9			[26]
September 16
September 23			[27]
September 30			[28]
October 7	"Meant to Fly"	Eva Avila	[29]
October 14			[30]
October 21			[31]
October 28
November 4
November 11
November 18
November 25	"The Saints Are Coming"	U2 and Green Day	[32]
December 2
December 9
December 16
December 23	"Meant to Fly"	Eva Avila	[33]
December 30			[34]

Digital singles

Issue date	Title	Artist(s)	Ref.
March 4	"You're Beautiful"	James Blunt	[35]
March 11			[36]
March 18			[37]
March 25			[38]
April 1			[39]
April 8			[40]
April 15			[41]
April 22			[42]
April 29	"Dani California"	Red Hot Chili Peppers	[43]
May 6			[44]
May 13	"SOS"	Rihanna	[45]
May 20	"Hips Don't Lie"	Shakira featuring Wyclef Jean	[46]
May 27			[47]
June 3			[48]
June 10			[49]
June 17	"Promiscuous"	Nelly Furtado featuring Timbaland	[50]
June 24			[51]
July 1			[52]
July 8			[53]
July 15			[54]
July 22			[55]
July 29			[56]
August 5			[57]
August 12	"Crazy"	Gnarls Barkley	[58]
August 19	"SexyBack"	Justin Timberlake	[59]
August 26			[60]
September 2			[61]
September 9			[62]
September 16			[63]
September 23			[64]
September 30			[65]
October 7			[66]
October 14	"Be Yourself and 5 Other Cliches"	Rock Star Supernova	[67]
October 21	"Chasing Cars"	Snow Patrol	[68]
October 28			[69]
November 4			[70]
November 11			[71]
November 18			[72]
November 25			[73]
December 2	"The Saints Are Coming"	U2 and Green Day	[74]
December 9			[75]
December 16	"Keep Holding On"	Avril Lavigne	[76]
December 23	"Wind It Up"	Gwen Stefani	[77]
December 30	"Say It Right"	Nelly Furtado featuring Timbaland	[78]