Lesieur is a last name, and may refer to:

• Art Lesieur (1907–1967), American ice hockey player
• Émile Lesieur (1885–1985), French rugby player
• Eugène Lesieur (1890–1975), French wrestler
• Jean-Pierre Lesieur (born 1935), French poet
• Georges Lesieur (1848–1931), French businessman
• Marie Lesieur (1799–1890), known as Marie Lesueur, French ballet dancer
• Stephen Lesieur, Swiss-born English diplomat