Leica may refer to:

• Ernst Leitz GmbH, later divided into:
  • Leica Biosystems GmbH, a cancer diagnostics company
  • Leica Camera AG, a German camera and optics manufacturer
  • Leica Geosystems AG, a Swiss manufacturer of surveying and geomatics equipment
  • Leica Microsystems GmbH, a German manufacturer of microscopes and other precision optics

• "Leica", a song from the album Akeldama by Faceless
• Leica (river), Romania
• Leica reel, a type of animatic production method for animation

• Laika (disambiguation)
• Lieka, a former settlement in Ethiopia