Leatherwood is a surname. Notable people with the surname include:

• Alex Leatherwood (born 1998), American football player
• Bryce Leatherwood (born 2000), American country singer
• Elmer O. Leatherwood (1872–1929), American politician
• Gavin Leatherwood (born 1994), American actor and singer
• Frank Leatherwood (born 1977), American football player
• Lillie Leatherwood (born 1964), American athlete
• Ray Leatherwood (1914–1996), American jazz double-bassist
• Robert N. Leatherwood (1844–1920), American businessman
• Tom Leatherwood (born 1956), American politician