Protein-coding gene in the species Homo sapiens
Laminin subunit alpha-1 is a protein that in humans is encoded by the LAMA1 gene .[ 5] [ 6]
Interactions Laminin, alpha 1 has been shown to interact with FBLN2 .[ 7] [ 8]
Role in pathology Mutations of the LAMA1 gene cause the Poretti–Boltshauser syndrome .
References
^ a b c GRCh38: Ensembl release 89: ENSG00000101680 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032796 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J (January 1990). "Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3". Genomics . 5 (4): 932–5. doi :10.1016/0888-7543(89)90136-5 . PMID 2591971 . ^ "Entrez Gene: LAMA1 laminin, alpha 1" .^ Utani A, Nomizu M, Yamada Y (January 1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences" . J. Biol. Chem . 272 (5): 2814–20. doi :10.1074/jbc.272.5.2814 ISSN 0021-9258 . PMID 9006922 . S2CID 24800195 . ^ Talts JF, Sasaki T, Miosge N, Göhring W, Mann K, Mayne R, Timpl R (November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues" . J. Biol. Chem . 275 (45): 35192–9. doi :10.1074/jbc.M003261200 ISSN 0021-9258 . PMID 10934193 . S2CID 36521395 .
Further reading
Haaparanta T, Uitto J, Ruoslahti E, Engvall E (1991). "Molecular cloning of the cDNA encoding human laminin A chain". Matrix . 11 (3): 151–60. doi :10.1016/s0934-8832(11)80153-8 . PMID 1714537 . Nissinen M, Vuolteenaho R, Boot-Handford R, et al. (1991). "Primary structure of the human laminin A chain. Limited expression in human tissues" . Biochem. J . 276 ( Pt 2) (Pt 2): 369–79. doi :10.1042/bj2760369 . PMC 1151101 PMID 2049067 . Taraboletti G, Rao CN, Krutzsch HC, et al. (1990). "Sulfatide-binding domain of the laminin A chain" . J. Biol. Chem . 265 (21): 12253–8. doi :10.1016/S0021-9258(19)38338-3 PMID 2373692 . Olsen D, Nagayoshi T, Fazio M, et al. (1989). "Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells". Lab. Invest . 60 (6): 772–82. PMID 2733383 . Leivo I, Engvall E (1986). "C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast" . J. Cell Biol . 103 (3): 1091–100. doi :10.1083/jcb.103.3.1091 . PMC 2114300 PMID 3488995 . Wewer UM, Gerecke DR, Durkin ME, et al. (1995). "Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas". Genomics . 24 (2): 243–52. doi :10.1006/geno.1994.1612 . PMID 7698745 . Yamada H, Shimizu T, Tanaka T, et al. (1994). "Dystroglycan is a binding protein of laminin and merosin in peripheral nerve". FEBS Lett . 352 (1): 49–53. doi :10.1016/0014-5793(94)00917-1 . PMID 7925941 . S2CID 17529055 . Moser TL, Enghild JJ, Pizzo SV, Stack MS (1993). "The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator" . J. Biol. Chem . 268 (25): 18917–23. doi :10.1016/S0021-9258(17)46714-7 PMID 8360181 . Yurchenco PD, Sung U, Ward MD, et al. (1993). "Recombinant laminin G domain mediates myoblast adhesion and heparin binding" . J. Biol. Chem . 268 (11): 8356–65. doi :10.1016/S0021-9258(18)53103-3 PMID 8463343 . Ancsin JB, Kisilevsky R (1997). "Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A" . J. Biol. Chem . 272 (1): 406–13. doi :10.1074/jbc.272.1.406 PMID 8995276 . S2CID 37912337 . Zahedi K (1997). "Characterization of the binding of serum amyloid P to laminin" . J. Biol. Chem . 272 (4): 2143–8. doi :10.1074/S0021-9258(19)78482-8 PMID 8999915 . Utani A, Nomizu M, Yamada Y (1997). "Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences" . J. Biol. Chem . 272 (5): 2814–20. doi :10.1074/jbc.272.5.2814 PMID 9006922 . S2CID 24800195 . Cáceres J, Brandan E (1997). "Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans". J. Cell. Biochem . 65 (2): 145–58. doi :10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U . PMID 9136074 . S2CID 43911847 . Chen M, Marinkovich MP, Veis A, et al. (1997). "Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin" . J. Biol. Chem . 272 (23): 14516–22. doi :10.1074/jbc.272.23.14516 PMID 9169408 . S2CID 7310763 . Schuger L, Skubitz AP, Zhang J, et al. (1997). "Laminin α1 Chain Synthesis in the Mouse Developing Lung: Requirement for Epithelial–Mesenchymal Contact and Possible Role in Bronchial Smooth muscle Development" . J. Cell Biol . 139 (2): 553–62. doi :10.1083/jcb.139.2.553 . PMC 2139794 PMID 9334356 . Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Arch. Immunol. Ther. Exp. (Warsz.) . 45 (2–3): 255–9. PMID 9597096 . O'Grady P, Thai TC, Saito H (1998). "The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR" . J. Cell Biol . 141 (7): 1675–84. doi :10.1083/jcb.141.7.1675 . PMC 2133008 PMID 9647658 . Ettner N, Göhring W, Sasaki T, et al. (1998). "The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan" . FEBS Lett . 430 (3): 217–21. doi :10.1016/S0014-5793(98)00601-2 PMID 9688542 . S2CID 84569969 . Ludwig HC, Rausch S, Schallock K, Markakis E (1999). "Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry". Anticancer Res . 19 (3A): 1747–52. PMID 10470109 .
