Kyo or KYO can refer to:

• Machiko Kyō (京 マチ子, 1924–2019), Japanese actress
• Nobuo Kyo (姜 暢雄, born 1979), Japanese actor
• Kyō Noguchi (野口 恭, 1939–2009), Japanese former professional boxer
• Kyo Kawakami (川上 叶, born 1995), Japanese kickboxer
• Kiuchi Kyō (木内 キヤウ, 1884–1964), Japanese educator and politician
• Kyo Koike (小池 恭, 1878-1947), Japanese-American poet
• Kyo Yoshida (吉田 杏, born 1995), Japanese rugby union player
• Kyo Maclear, Canadian novelist and children's author
• Kyo Sato (佐藤 響, born 2000), Japanese footballer
• Hanabasami Kyo, Japanese VTuber
• Kyo Kaneko, VTuber affiliated with Nijisanji
• Kyo (musician), Japanese singer-songwriter
• Kyo, Japanese singer of the rock band D'erlanger
• An alias of English singer-songwriter Carol Leeming

• Kyo Kusanagi, a main character in the video game series King of Fighters
• Kyo Sohma, a character in the manga series Fruits Basket
• Kyō Fujibayashi, a character in the visual novel Clannad
• Demon Eyes Kyo, a character in the manga series Samurai Deeper Kyo

• Kyo, a 1996 Japanese manga series by Ryōji Minagawa

• Kyo (band), a French rock band
  • Kyo (album)

• Kyo Ya, was a Japanese restaurant in New York City
• Three villages in County Durham, England:
  • East Kyo
  • West Kyo
  • New Kyo
• Kyo Burn, the name of the section of the River Team, near the villages
• another name for Kyoto, a city in Japan
• KYO, the Indian Railways station code for Khandikar railway station, Assam, India

• Kyo, the ISO 639-3 code for Klon language, Indonesia