Klo or KLO may refer to:

• Kalibo International Airport (IATA: KLO), Philippines
• Kamtapur Liberation Organisation, India
• Karabakh Liberation Organization (Qarabağ Azadlıq Təşkilatı), Azerbaijan
• Korea Liaison Office, an American intelligence unit in the Korean War
• KLO-FM, a radio station serving Coalville, Utah, US
• KMES, a radio station (1430 AM) licensed to serve Ogden, Utah, United States, which held the call sign KLO from 1929 to 2020
• Lhoba people of Southeastern Tibet, also known as "Klo"
• A neighbourhood of Kelowna, British Columbia, Canada