Khayat, Khayyat is an Arabic-language occupational surname, literally meaning "tailor". Notable people with the surname include:

• Khayat (singer), Ukrainian singer
• Bill Khayat (born 1973), American football coach
• David Khayat (born 1956), French oncologist
• Ed Khayat (born 1935), American football player
• Jana Khayat, British businesswoman
• Jean Khayat (born 1942), Tunisian Olympic fencer
• Mirna Khayat, Lebanese music video director
• Nadir Khayat, known by the stage name RedOne, Morocco-born Swedish producer and songwriter
• Robert Khayat (born 1938), American academic, Chancellor of the University of Mississippi

• Dora Khayatt (1910–1986) Egyptian-born American painter
• Regina Khayatt (1881–1942) Egyptian educator, feminist, suffragist, and temperance worker
• Audishu V Khayyath, patriarch of the Chaldean Catholic Church in 1894–1899

• Al Khayat (name list)