Protein-coding gene in the species Homo sapiens
Kinesin family member 5B (KIF5B) is a protein that in humans is encoded by the KIF5B gene .[ 5] [ 6] kinesin family of motor proteins .
Interactions KIF5B has been shown to interact with:
References
^ a b c GRCh38: Ensembl release 89: ENSG00000170759 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006740 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Navone F, Niclas J, Hom-Booher N, Sparks L, Bernstein HD, McCaffrey G, Vale RD (Jun 1992). "Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells" . The Journal of Cell Biology . 117 (6): 1263–75. doi :10.1083/jcb.117.6.1263 . PMC 2289507 PMID 1607388 . ^ "Entrez Gene: KIF5B kinesin family member 5B" .^ a b c Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry . 41 (50): 14906–15. doi :10.1021/bi026417u . PMID 12475239 . ^ a b Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins" . The Journal of Biological Chemistry . 273 (25): 15395–403. doi :10.1074/jbc.273.25.15395 PMID 9624122 . ^ a b Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants" . The Journal of Cell Biology . 146 (6): 1277–88. doi :10.1083/jcb.146.6.1277 . PMC 2156125 PMID 10491391 . ^ Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T (Apr 2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry . 41 (17): 5566–72. doi :10.1021/bi015946f . PMID 11969417 .
Further reading
Niclas J, Navone F, Hom-Booher N, Vale RD (May 1994). "Cloning and localization of a conventional kinesin motor expressed exclusively in neurons". Neuron . 12 (5): 1059–72. doi :10.1016/0896-6273(94)90314-X . PMID 7514426 . S2CID 32927183 . Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD (Apr 1996). "Crystal structure of the kinesin motor domain reveals a structural similarity to myosin" . Nature . 380 (6574): 550–5. Bibcode :1996Natur.380..550J . doi :10.1038/380550a0 . PMC 2851642 PMID 8606779 . Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins" . The Journal of Biological Chemistry . 273 (25): 15395–403. doi :10.1074/jbc.273.25.15395 PMID 9624122 . Tanaka Y, Kanai Y, Okada Y, Nonaka S, Takeda S, Harada A, Hirokawa N (Jun 1998). "Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria" . Cell . 93 (7): 1147–58. doi :10.1016/S0092-8674(00)81459-2 PMID 9657148 . S2CID 17524297 . Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants" . The Journal of Cell Biology . 146 (6): 1277–88. doi :10.1083/jcb.146.6.1277 . PMC 2156125 PMID 10491391 . Ong LL, Lim AP, Er CP, Kuznetsov SA, Yu H (Oct 2000). "Kinectin-kinesin binding domains and their effects on organelle motility" . The Journal of Biological Chemistry . 275 (42): 32854–60. doi :10.1074/jbc.M005650200 PMID 10913441 . Kanai Y, Okada Y, Tanaka Y, Harada A, Terada S, Hirokawa N (Sep 2000). "KIF5C, a novel neuronal kinesin enriched in motor neurons" . The Journal of Neuroscience . 20 (17): 6374–84. doi :10.1523/JNEUROSCI.20-17-06374.2000 . PMC 6772948 PMID 10964943 . Setou M, Seog DH, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, Hirokawa N (May 2002). "Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites". Nature . 417 (6884): 83–7. Bibcode :2002Natur.417...83S . doi :10.1038/nature743 . PMID 11986669 . S2CID 4400494 . Hakimi MA, Speicher DW, Shiekhattar R (Oct 2002). "The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis" . The Journal of Biological Chemistry . 277 (40): 36909–12. doi :10.1074/jbc.C200434200 PMID 12191989 . Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry . 41 (50): 14906–15. doi :10.1021/bi026417u . PMID 12475239 . Macioce P, Gambara G, Bernassola M, Gaddini L, Torreri P, Macchia G, Ramoni C, Ceccarini M, Petrucci TC (Dec 2003). "Beta-dystrobrevin interacts directly with kinesin heavy chain in brain" . Journal of Cell Science . 116 (Pt 23): 4847–56. doi :10.1242/jcs.00805 PMID 14600269 . Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL (Jul 2004). "The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B". Biochemical and Biophysical Research Communications . 319 (3): 987–92. doi :10.1016/j.bbrc.2004.05.069 . PMID 15184079 . Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" . Current Biology . 14 (16): 1436–50. Bibcode :2004CBio...14.1436J . doi :10.1016/j.cub.2004.07.051 PMID 15324660 . S2CID 2371325 . Su Q, Cai Q, Gerwin C, Smith CL, Sheng ZH (Oct 2004). "Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons". Nature Cell Biology . 6 (10): 941–53. doi :10.1038/ncb1169 . PMID 15459722 . S2CID 6875457 . Brickley K, Smith MJ, Beck M, Stephenson FA (Apr 2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin" . The Journal of Biological Chemistry . 280 (15): 14723–32. doi :10.1074/jbc.M409095200 PMID 15644324 . Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer" . Molecular & Cellular Proteomics . 4 (6): 785–95. doi :10.1074/mcp.M500021-MCP200 PMID 15778465 .
External links Overview of all the structural information available in the PDB for UniProt : P33176 PDBe-KB .
