José Luis Rodríguez
José Luis Rodríguez may refer to:
- José Luis Rodríguez Vélez (1915–1984), Panamanian musician
- José Luis Rodríguez (singer) (born 1943), El Puma, Venezuelan singer and actor
- José Luis Rodríguez Zapatero (born 1960), former Prime Minister of Spain (2004–2011)
- José Luis Rodríguez (footballer, born 1963), El Puma, former Argentine football striker
- José Luis Loreto (José Luis Rodríguez Loreto, born 1971), former Spanish football striker
- José Luis Rodríguez Pittí (born 1971), Panamanian writer, documentary photographer, and computer systems engineer
- José Luis Rodríguez Aguilar (born 1994), Chilean cyclist
- José Luis Rodríguez (footballer, born 1997), Uruguayan footballer
- José Luis Rodríguez (footballer, born 1998), Panamanian footballer
- José Luis Rodríguez Jiménez (born 1961), Spanish historian