José Enrique is a Spanish given name. It may refer to:

• José Enrique (footballer) (born 1986), Spanish footballer
• José Enrique Angulo (born 1995), Ecuadorian footballer
• José Enrique Arrarás (born 1937), Puerto Rican politician
• José Enrique Caraballo (born 1996), Venezuelan footballer
• José Enrique Cima (born 1952), Spanish cyclist
• José Enrique García (born 1967), Uruguayan footballer
• José Enrique Gutiérrez (born 1974), Spanish cyclist
• José Enrique Manica (born 1993), Mexican footballer
• José Enrique Moyal (1910–1998), mathematical physicist and engineer
• José Enrique Pedreira (1904–1959), Puerto Rican composer
• José Enrique Peña (born 1963), Uruguayan footballer
• José Enrique Porto (born 1977), Spanish Paralympic cyclist
• José Enrique Ramírez (born 1992), Dominican Republic baseball player
• José Enrique Rodó (1872–1917), Uruguayan essayist
• José Enrique Sarabia (born 1940), Venezuelan poet, musician
• José Enrique Serrano (born 1943), American politician
• José Enrique Varela (1891–1951), Spanish military officer