John Gough may refer to:

• John Gough (American football) (1900–1935), American football player and coach
• John Gough (Canadian football) (born 1920s), Canadian football player
• John Gough (footballer), Irish football goalkeeper
• John Gough (referee) (born 1937), Irish Gaelic games match official
• John Gough (sport shooter) (1929–2023), English sport shooter

• John Gough (actor), American actor in the silent film era, including in Wives and Other Wives
• John Gough (British Army officer) (1871–1915), British general and recipient of the Victoria Cross
• John Gough (composer) (1903–1951), Australian-born composer, radio producer and radio playwright who relocated to the UK and worked for the BBC
• John Gough (natural philosopher) (1757–1825), English natural and experimental philosopher
• John Bartholomew Gough (1817–1886), American temperance orator
• John George Gough (1848–1907), co-founder of the New South Wales Labour Party
• John Wiedhofft Gough (1900–1976), Welsh historian